Top > ご連絡など > ケアマネジャーの介護保険NEWS > 【介護支援専門員 NEWS】パーキンソン薬がアルツハイマー治療に効果――九州大
【介護支援専門員 NEWS】パーキンソン薬がアルツハイマー治療に効果――九州大
同大大学院医学研究院神経内科学分野の大八木保政准教授ら研究グループが行った実験は、海外の抗パーキンソン病薬「アポモルフィン」を使用。アルツハイマー病のモデルマウスに週1回1カ間、アポモルフィンを皮下注射し、マウスを直径約1メートルのプールで泳がせて上陸できるゴール台の位置を記憶させ、24時間後にゴール台なしで60秒間泳がせた軌跡を解析した。
その結果、アポモルフィン投与前後の比較では、ゴール場所の記憶に明らかな改善がみられ、脳の老人斑に蓄積するアミロイドΒ(ベータ)たんぱく質が減少した。
【アポモルフィン(APO)投与によるマウス遊泳結果】
アポモルフィンは、海外でパーキンソン病患者の皮下注射薬として使用されているが日本では承認されていない。同研究グループは今後、アルツハイマー患者への臨床研究を実施しながら、より副作用が少なく効果の高い薬剤の開発を進め、新たなアルツハイマー病の治療戦略として提唱する予定。本研究結果は、米国神経学雑誌Annals of Neurology (アナルズ・オブ・ニューロロジー)オンライン版でも発表されている。
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