Top > ご連絡など > ケアマネジャーの介護保険NEWS > 【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ

【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ

肥満になると、血管内皮細胞のインスリン作用が低下し、筋肉の毛細血管が十分に拡張しなくなるため、インスリンが届きにくく、筋肉での糖の取り込みに障害が生じることを、東大大学院の門脇孝教授らの研究グループが解明した。最大の「糖の消費臓器」である筋肉のインスリン抵抗性を克服することは、2型糖尿病の治療にとって重要なカギ。研究では、このインスリン作用を正常化し、血管の拡張を促すことで、糖の取り込みが改善されることも明らかにしており、門脇教授は「世界が驚くような画期的な発見。全く新しい標的の治療薬の開発につながる」としている。

肥満などによって引き起こされるインスリン抵抗性は、最初に筋肉で現われる。しかし、血液中のインスリンが毛細血管の血管内皮細胞を通り、筋肉へと移行するメカニズムは、これまで詳しく分かっていなかった。

 研究グループは、血管内皮細胞でインスリン作用を伝達する「インスリン受容体基質2(IRS2)」に着目。IRS2を欠損させたマウスでは、食後にインスリンが分泌されても、血管を拡張する酵素(eNOS)が活性化されず、正常なマウスの半分ほどしかインスリンが筋肉に届かないため、糖の取り込みに障害が生じることが分かった。
 また、この治療法として、慢性閉塞性動脈硬化症などの治療に用いられる「プロスタグランジンI2アナログ(ベラプロストナトリウム)」に注目。この薬剤は、eNOSを増やして血管を拡張する作用があり、IRS2欠損マウスに投与したところ、糖の取り込みが改善された。

 一方、高脂肪食を与えて肥満させたマウスは、慢性的な高インスリン血症により、血管内皮細胞のIRS2が半分程度に減少することを確認。欠損マウスと同じように、eNOSの活性化と毛細血管の拡張、インスリンの移行量がそれぞれ低下し、筋肉の糖取り込みに障害が生じることや、ベラプロストナトリウムの投与で改善されることを明らかにした。

 門脇教授は、「インスリン抵抗性を改善する従来の薬剤で十分な効果が得られなかったのは、治療ターゲットから血管内皮細胞が抜け落ちていたためとも考えられる」とし、血管内皮細胞のIRS2の増加やeNOS活性化を促すなど、新たな糖尿病薬の開発に向けた可能性を指摘している。研究は米科学誌Cell Metabolism3月2日号で発表した。
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NEWS】被災者の介護保険資格認定「転入先独自で」- 東日本大震災などで厚労省 【介護支援専門員 NEWS】被災地での認知症支援ガイドを作成- 東京センター 【介護支援専門員 NEWS】第23回社会福祉士国家試験合格について【介護支援専門員 NEWS】支払い困難な被災者の医療費自己負担を猶予- 住居全壊など対象に厚労省【介護支援専門員 NEWS】介護サービス、燃料不足には代替サービスも- 担当者会議は必要とせず 【介護支援専門員 NEWS】厚労省、被災施設に介護職員など派遣へ- 実態把握を開始【介護支援専門員 NEWS】地震でケアマネ実務研修も各地延期、確認を【介護支援専門員 NEWS】地震並びに津波により被災した要介護者等への対応について――厚労省【介護支援専門員 NEWS】医療・介護の現場に広がる"輪番"の不安- 東日本大震災 【介護支援専門員 NEWS】介護保険法等改正案を閣議決定- 政府【介護支援専門員 NEWS】訪看ステーションの一人開業認める――規制仕分け【介護支援専門員 NEWS】パーキンソン薬がアルツハイマー治療に効果――九州大【介護支援専門員 NEWS】レセプト突合・縦覧点検「歴史的な転換点」- 支払基金・河内山理事長 【介護支援専門員 NEWS】「認知症サービスの検討部会必要」- 大森・介護給付費分科会長 【介護支援専門員 NEWS】多世代が交流できる高齢者住宅を【介護支援専門員 NEWS】ケアマネ支援に包括配置 「地域連携推進員」とは【介護支援専門員 NEWS】介護人材に7段階の段位導入を検討- 政府【介護支援専門員 NEWS】耐火構造の特養への融資、30年償還に- 社会・援護局 【介護支援専門員 NEWS】訪問介護の利用は掃除がトップ――09年介護サービス施設・事業所調査結果【介護支援専門員 NEWS】社福減免で生活保護者の個室利用可能に 【介護支援専門員 NEWS】5つに1つの世帯にケアラー- NPO「アラジン」とケアラー連盟が調査 【介護支援専門員 NEWS】在宅医療提供体制の整備に1億7000万円の予算――厚労省【介護支援専門員 NEWS】認定調査員テキスト改訂版(2011年3月改訂)、公表!――厚労省【介護支援専門員 NEWS】GEとソフトバンクが医療IT事業で提携【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ 【介護支援専門員 NEWS】訪介&訪看、小規模多機能&訪看など複合型創設へ【介護支援専門員 NEWS】訪問ヘルパー1年目で年収300万の会社とは?――株式会社らいふ【介護支援専門員 NEWS】「複合型サービス」などの創設盛り込む- 介護保険法等改正案要綱 【介護支援専門員 NEWS】特定施設事業者から高齢者住宅の整備に異論- 特定協研究会 高齢者の買い物問題、見守りなどの解決めざす――都市再生機構新たに「介護支援専門員研修改善事業」実施へ――厚労省会議【介護支援専門員 NEWS】ケアマネ法の制定と「大学」設置を- 木村会長 【介護支援専門員 NEWS】ケアマネジメントの実態把握調査を実施へ 【介護支援専門員 NEWS】24時間訪問介護、深夜帯の需要に疑問- セントケア 【介護支援専門員 NEWS】ビフィズス菌がO-157感染予防に効果――理化学研究所ほか共同研究で判明【介護支援専門員 NEWS】介護職員必見! 厚労省、YouTubeで「インフルエンザ一問一答」発信【介護支援専門員 NEWS】フジサンケイグループ、介護ビジネスに参入【介護支援専門員 NEWS】予算1億円!地域包括や民生委員が高齢者戸別訪問を開始――杉並区【介護支援専門員 NEWS】「ビジョン付き増税」が絶対条件- 民主・抜本改革調査会 【介護支援専門員 NEWS】認知症ケアや感染症対策の実践例を報告- 東京都介護老人保健施設大会 【介護支援専門員 NEWS】12年度介護報酬改定「プラマイ0.5%」- みずほ証券・渡辺氏が予測 【介護支援専門員 NEWS】ニチイ学館、訪問看護を毎年33-40拠点 【介護支援専門員 NEWS】ジェネリック医薬品、使用率20%に上昇――協会調べ【介護支援専門員 NEWS】60歳以上の7%が要介護認定を受け、40%が家計は赤字――内閣府調査【介護支援専門員 NEWS】お泊まりデイ事業所、半数に「毎日宿泊者」- 都の緊急調査 【介護支援専門員 NEWS】がん拠点病院、11施設を新たに指定へ【介護支援専門員 NEWS】新高齢者医療制度「今国会に法案提出」- 細川厚労相が改めて強調 【介護支援専門員 NEWS】特養ホームの民間運営を特区内で容認 - 総合特区法案【介護支援専門員 NEWS】高齢者にみられる代表的な身体症状【介護支援専門員 NEWS】12年度介護報酬改定の基本的視点を提示- 厚労省が介護給付費分科会に【介護支援専門員 NEWS】介護施設の総量規制「堅持を」- 政令市などの担当課長が要望 【介護支援専門員 NEWS】限度額超過者の8割超がサービス2種類以下- 介護給付費分科会 【介護支援専門員 NEWS】地域包括支援センター職員数、大幅に増加 【介護支援専門員 NEWS】ユニット型個室の居住費助成を拡充- 横浜市が10月から【介護支援専門員 NEWS】ユニット型個室の居住費助成を拡充- 横浜市が10月から 【介護支援専門員 NEWS】24時間訪問介護、エリア担当見送りで調整- 検討会最終報告で 【介護支援専門員 NEWS】国保収納率、2年連続で過去最低を更新 【介護支援専門員 NEWS】介護未経験者雇用の助成金廃止で経過措置- 厚労省が周知 【介護支援専門員 NEWS】「GHと小規模多機能の一元化を」 【介護支援専門員 NEWS】ケアマネ業務せず不正請求、指定取り消しへ- 神奈川県 【中医協】医療費の伸び率は3.9% 【介護支援専門員 NEWS】安心生活創造事業で論点を整理- 厚労省検討会 【介護支援専門員 NEWS】医療・福祉の就業者、増加幅が全産業で最大- 労働力調査 共通番号制度、導入は15年1月から- 政府・実務検討会 医療・福祉の就業者、増加幅が全産業で最大- 労働力調査 新たな高齢者医療制度、「13年3月施行」を強調-細川厚労相【介護支援専門員 NEWS】歯を失うと認知症になりやすい- リスク1.9倍、厚労省研究班が調査 【介護支援専門員 NEWS】高齢者住宅の供給割合を3-5%に- 住生活基本計画案 【介護支援専門員 NEWS】アルツハイマー型認知症治療薬「メマリー錠」販売承認取得【介護支援専門員 NEWS】要介護認定の有効期間、上限延長でパブコメ募集―厚労省【介護支援専門員 NEWS】24時間巡回型、公募式は民間参入制限だ【介護支援専門員 NEWS】ケアマネは「介護保険サービス以外にも注目を」【介護支援専門員 NEWS】次期改定での介護報酬アップ「有効な財源確保策を示せず厳しい」 【介護支援専門員 NEWS】厚労省、法改正で重大労働法規違反は指定取消に!【介護支援専門員 NEWS】介護福祉士国試、実務経験者に「450時間研修」義務化へ【介護支援専門員 NEWS】24時間巡回介護で国「協力を」、都は「疑問」―在宅協セミナー【介護支援専門員 NEWS】複合型事業所、「当面は小規模多機能と訪問看護で」【介護支援専門員 NEWS】やさしい手が法改正で生活援助切り捨てを示唆【介護支援専門員 NEWS】 「抜き打ち検査」「夜間サービスの質の確保」を提言【介護支援専門員 NEWS】国保などの保険医療費、高知がトップ【介護支援専門員 NEWS】虚血性心疾患治療の現状と将来展望――民間調査【介護支援専門員 NEWS】「消費税25%払ってもお年寄りが安心できる制度に」―ワタミ渡邉会長【介護支援専門員 NEWS】「抜き打ち調査」で質の確保を―特養を良くする会が細川厚労相に提言 【介護支援専門員 NEWS】与謝野担当相、社会保障費は「無理に削れない」【介護支援専門員 NEWS】医療行為も対応する「緊急ショートステイ事業」開始――杉並区【介護支援専門員 NEWS】介護従事者の半数以上「要介護認定は必要だが簡素化を」-淑徳大・結城准教授ら【介護支援専門員 NEWS】厚生労働省、介護福祉士・社会福祉士の受験料改定で意見募集【介護支援専門員 NEWS】病院の病床数、1年間で8600床減-10月末概数【介護支援専門員】アルツハイマー治療薬は2,900億市場に――民間調査【介護支援専門員】アルツハイマー治療薬は2,900億市場に――民間調査【介護支援専門員 NEWS】「潜在ヘルパー」有資格者の79%【介護支援専門員 NEWS】サービス提供責任者の責務に介護報酬を―ホームヘルパー協会が要望書【介護支援専門員 NEWS】「高齢者向け食品・飲料購入のきっかけはケアマネジャー」電通調査結果【介護支援専門員 NEWS】厚生労働省、介護給付費実態調査月10月分を公表【介護支援専門員 NEWS】介護業界売上トップ10!2000億超の企業は?――帝国データバンク【介護支援専門員 NEWS】健康状態の悪化や、退職の割合に介護が影響【介護支援専門員 NEWS】厚労省の社会保障検討本部が発足【介護支援専門員 NEWS】「どこでもMY病院」など情報化促進に15億円-経産省11年度予算案【介護支援専門員 NEWS】世界80カ国で承認の2型糖尿病治療剤「パイエッタ」発売【介護支援専門員 NEWS】29兆円のうち、介護2兆2,037億円――平成23年度予算案【介護支援専門員 NEWS】「地域医療支援センター」に意見が集中―社保審医療部会【介護支援専門員 NEWS】サービス付き高齢者住宅、24時間介護との組み合わせで【介護支援専門員 NEWS】サービス付き高齢者住宅の促進に325億円―国交省11年度予算案【介護支援専門員 NEWS】一部ユニット型施設、省令改正で廃止へ【介護支援専門員 NEWS】来年度の平均保険料率9.5%に引き上げへ-補助率の据え置き受け入れ【介護支援専門員 NEWS】認知症の要介護認定について【介護支援専門員 NEWS】「ケアプラン有料化」見送り!厚労相が改正6要点を表明!【介護支援専門員 NEWS】新規アルツハイマー病治療薬などの承認を了承―薬事分科会【介護支援専門員 NEWS】来年度予算案を閣議決定、厚労省分は約29兆円【介護支援専門員 NEWS】横浜の市民団体、配食サービス時の認知症見守りハンドブック発行【介護支援専門員 NEWS】「福祉士研修の大幅削減はバナナの叩き売り」――検討会レポ2【介護支援専門員 NEWS】民主政調、介護保険改革の提言を決定―細川厚労相に提出【介護支援専門員 NEWS】ケアマネ対象の医療研修など「10年後の東京」を策定――東京都【介護支援専門員 NEWS】交付金の影響でケアマネも1.1万円昇給【介護支援専門員 NEWS】新高齢者医療制度、国保のあり方など地方と協議へ―厚労省方針【介護支援専門員 NEWS】他国に比べて高コスト体質の日本の介護保険【介護支援専門員 NEWS】「重症」の医療区分1の患者が急増―医療療養病床【介護支援専門員 NEWS】「利用者負担導入反対決議文」を厚労省に提出――日本介護支援員協会【介護支援専門員 NEWS】マクドナルドが高齢者宅へ宅配開始、創業40年で初!【介護支援専門員 NEWS】介護職の医行為、2012年実施へ【介護支援専門員 NEWS】ケアマネ試験、合格率は過去最低の20.51%【介護支援専門員 NEWS】「介護保険制度改正ができないなら、政権担当能力はない」【介護支援専門員 NEWS】障がい者改革会議、現状認識に関係省庁と隔たり【介護支援専門員 NEWS】介護職員の医行為の範囲など示した中間まとめを了承―厚労省検討会【介護支援専門員 NEWS】介護療養廃止「3年延期」などの提言を大筋了承―民主・厚労部門会議【介護支援専門員 NEWS】成年後見制度の改善求め厚労相らに提言―日本社会福祉士会【介護支援専門員 NEWS】600万人の高齢「買い物弱者」支援マニュアル―経産省が公表 【介護支援専門員 NEWS】「介護なんでも110番」電話殺到で対応は約3%【介護支援専門員 NEWS】シルバーマークは「時代的役割終えた」?―省内仕分けで議論【介護支援専門員 NEWS】「男女雑魚寝」「2年連泊」、お泊まりデイの実態調査を―共産都議団【介護支援専門員 NEWS】平成22年 介護保険部会の取りまとめ【介護支援専門員 NEWS】精神障害者への訪問支援で大幅なコストダウンも―民主PTがヒアリング【介護支援専門員 NEWS】首都圏の介護事業者団体「地域係数見直しを」―細川厚労相に要望書【介護支援専門員 NEWS】24時間巡回型に1.5億、医行為研修2.8億円計上――第2次補正予算案【介護支援専門員 NEWS】介護療養型医療施設は「医療・介護の連携にベストな施設」【介護支援専門員 NEWS】高いレベルの介護福祉士、職能団体が認定―厚労省案【介護支援専門員 NEWS】都が介護事業所の指定取り消しへ、1億5千万円超の返還求める【介護支援専門員 NEWS】特養も有料老人ホームも高専賃も「高齢者住宅」―類型簡素化を ケアプラン有料化は未決着、賛否両論併記で国会提出!――社保審レポ【介護福祉士 NEWS】24時間訪問介護やお泊まりデイは区市町村が指定を―都が提言【介護支援専門員 NEWS】介護職員交付金、報酬への組み入れに疑問も―民主・介護WT【介護支援専門員 NEWS】介護保険、4割強が税負担を容認―内閣府調査【介護支援専門員 NEWS】新規アルツハイマー治療薬2品目の承認を了承―医薬品第一部会【介護支援専門員 NEWS】高専賃での居宅介護支援、集中減算に批判―高齢者集合住宅研究大会【介護支援専門員 NEWS】認知症患者の見守りネット、稼働の自治体は1割未満【介護支援専門員 NEWS】定額訪問介護、「報酬28万―30万円必要」―ジャパンケア・対馬会長【介護支援専門員 NEWS】介護保険制度の見直しに向けた素案を提出―厚労省【介護支援専門員 NEWS】第5期の介護保険料、1000円超アップの5200円―厚労省が試算【介護支援専門員 NEWS】障害者自立支援法改正案を可決―衆院厚労委【介護支援専門員 NEWS】「国保の都道府県単位化」に異論なし―民主・高齢者医療WT【介護支援専門員 NEWS】介護予防事業の再仕分け、前回同様「予算要求の縮減」【介護支援専門員 NEWS】「ケアプランの利用者負担は断固反対」――JCMA提言【介護支援専門員 NEWS】「介護職員の医行為は、医療・介護の新たな線引きを考える糸口」【介護支援専門員 NEWS】仕事に関する相談窓口、職場に「なし」が9割――ヘルパー満足度調査【介護支援専門員 NEWS】「介護政策、財源足りない」―小宮山厚労副大臣【介護支援専門員 NEWS】「地域医療支援センター」に意見が集中―社保審医療部会【介護支援専門員 NEWS】『VIPSですすめるパーソン・センタード・ケア』発行【介護支援専門員 NEWS】静岡で過去最大級の報酬不正受給―介護療養型医療施設の指定取り消しへ【介護支援専門員 NEWS】特養の運営「社福に限定を」約5割―施設長有志団体【介護支援専門員 NEWS】75歳以上の医療費負担、「税金の割合増で」が4割超【介護支援専門員 NEWS】全老健、老健の医療に関する意見書を発表【介護支援専門員 NEWS】【11月13日】ケアマネ独立開業セミナー 【介護支援専門員 NEWS】全老健、介護保険制度に対する意見書を発表【介護支援専門員 NEWS】通所サービスの見直しも―厚労省老人保健課長【介護支援専門員 NEWS】日本介護福祉士会が人員配置、処遇改善などの提言書を提出【介護支援専門員 NEWS】末期がんで福祉用具貸与、軽度者でも保険適用可能―厚労省が事務連絡【介護支援専門員 NEWS】区分支給限度基準額の運用見直しなどを提言―ホームヘルパー協議会【介護支援専門員 NEWS】ケアプラン作成「利用者負担」導入を提示――社会保障審議会【介護支援専門員 NEWS】介護福祉士資格の600時間研修案「現実的ではない」【介護支援専門員 NEWS】1万人超の障害関係者が「自立支援法の廃止を」【介護支援専門員 NEWS】介護職員養成13万円、救急搬送7,600円――埼玉県「行政の値札」【介護支援専門員 NEWS】 夜間訪問介護で16億円ムダ、端末機は倉庫保管でホコリかぶる【介護支援専門員 NEWS】ユニット型特養の約1割が赤字【介護支援専門員 NEWS】介護サービス費用額、6000億円超える―給付費実態調査・8月分【介護支援専門員 NEWS】 来年アリセプト以外の新薬認可【介護支援専門員 NEWS】介護福祉士の医行為追加研修と上級資格創設――厚労省会議 【介護支援専門員 NEWS】特養入所申し込み者、実際の待機は22.5%―厚労省 【介護支援専門員 NEWS】1万円増えた!ケアマネ月給26万3,754円――日本介護クラフトユニオン調査介護支援専門員のための介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS平成21年介護支援専門員実務研修受講試験 合格率介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS平成21年介護支援専門員実務研修受講試験 都道府県別 合格率介護支援専門員の介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員のための介護保険NEWS直通!!ケアマネジャーサポート事例介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員の介護保険NEWS介護支援専門員のためのNEWSケアマネジャーのための介護保険NEWSケアマネジャーのための介護保険NEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWSケアマネジャーのための介護保険NEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のためのNEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援介護支援専門員のための介護保険NEWSケアマネジャーのための介護保険NEWS介護支援専門員のための介護保険NEWS介護支援専門員のための介護保険NEWSケアマネージャーの介護保険NEWSケアマネージャーの介護保険NEWS