Top > ご連絡など > ケアマネジャーの介護保険NEWS > 【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ
【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ
肥満などによって引き起こされるインスリン抵抗性は、最初に筋肉で現われる。しかし、血液中のインスリンが毛細血管の血管内皮細胞を通り、筋肉へと移行するメカニズムは、これまで詳しく分かっていなかった。
研究グループは、血管内皮細胞でインスリン作用を伝達する「インスリン受容体基質2(IRS2)」に着目。IRS2を欠損させたマウスでは、食後にインスリンが分泌されても、血管を拡張する酵素(eNOS)が活性化されず、正常なマウスの半分ほどしかインスリンが筋肉に届かないため、糖の取り込みに障害が生じることが分かった。
また、この治療法として、慢性閉塞性動脈硬化症などの治療に用いられる「プロスタグランジンI2アナログ(ベラプロストナトリウム)」に注目。この薬剤は、eNOSを増やして血管を拡張する作用があり、IRS2欠損マウスに投与したところ、糖の取り込みが改善された。
一方、高脂肪食を与えて肥満させたマウスは、慢性的な高インスリン血症により、血管内皮細胞のIRS2が半分程度に減少することを確認。欠損マウスと同じように、eNOSの活性化と毛細血管の拡張、インスリンの移行量がそれぞれ低下し、筋肉の糖取り込みに障害が生じることや、ベラプロストナトリウムの投与で改善されることを明らかにした。
門脇教授は、「インスリン抵抗性を改善する従来の薬剤で十分な効果が得られなかったのは、治療ターゲットから血管内皮細胞が抜け落ちていたためとも考えられる」とし、血管内皮細胞のIRS2の増加やeNOS活性化を促すなど、新たな糖尿病薬の開発に向けた可能性を指摘している。研究は米科学誌Cell Metabolism3月2日号で発表した。
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【介護支援専門員 NEWS】2型糖尿病、筋肉の糖取り込み障害を解明- 新たな治療法に可能性・東大グループ
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Theres a story in Matthew about dead people coming back to life, unburying themselves and then walking into the city and appearing to many other people. That story isnt in any other gospels. I wonder why. Hmmm. because it never happened?
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It was always PG. Brief nudity in PG movies was possible even after PG-13 came along. Logans Run had a lot more skin than this movie.
1) Right after the trade, Krstic went on a tear, and the Celtics shot off 6 straight. Without that production from Krstic, do the Celtics still win all those games?
Ummmmmmmmmmmm Now I am Hungry and want some wine..Hot Turkey Sandwich and a Glass of Merlot.Sounds Great to me
sorry to post this on Gatesys recap which I LOVE btw but I didnt know where else to vent.
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Oopsmight have spoken too soon. Young teams dont know how to play late in games, especially playoff games. Total self-destruction. Can they now learn to win? Go Cs.
Definitely. Indie is just an icon. That franchise was the last of a dying breed almost. That and Romancing the Stone are some of the last great TRUE adventure movies. Nowadays they turn way too much towards the action part of action-adventure and mostly abandon the adventure part. Thats part of the reason I was initially excited about the Uncharted movie, thinking theyd get back to making a good adventure movie. Looks like theyll mess that up though.
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but in a very (too) polite manner
Beans is a sell out.. and fif has done it again!
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Except for very young hitters who race through the minors, K/BB ratios do not tend to improve going from the minors to the majors; if anything, they get worse. For instance, Ron Kittle, another "specimen," had a passable 2.1 ratio in the minors (including a fine 109/74 season at AAA), but had a 3.2 K/BB ratio in the majors.
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eyeswideopen I have to agree with you on this 100%, but I dont consider myself older at 36 heh. I took economic classes and did stock away some money, unfortunately I got laid off in 2002 and went through that and then some trying to keep up and am just now getting back to even and trying to rebuild what savings I had. We all go through rough patches, but I believe in Capitalism, though I also am not foolish enough to believe that government can sit idly by and not regulate it at all. Hopefully the worst of the recession is over and the growth trends are back on the way. I am not saying they are or are not, just I hope that the article is right, as I may have taken personal econ classes I am about as clueless as a nun in a dildo factory when it comes to national or international economics.
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